“In vivo acute toxicity and anti-gastric evaluation of a novel dichloro Schiff base: Bax and HSP70 alteration”
Novel dichloro-substituted Schiff base complex, 2, 2′- [-1, 2-cyclohexanediylbis(nitriloethylidyne)] bis(4-chlorophenol) (CNCP) is safe for use and it has significant gastroprotective potential via the protection of stomach epithelium against ethanol-induced damage.
CNCP could drastically enhance the activities of SOD and CAT, while it could retard the level of MDA in stomach tissue homogenates and could remarkably elevate the level of PGE2.
CNCP could increase glycoprotein contents, and moreover it could cause up-regulation of HSP70 protein and down-regulation of Bax protein, indicating its effectiveness in regulating apoptosis. Study provides convincing evidence that CNCP possesses gastroprotective activity in gastric ulcer models via the pathways, leading to the increase of the levels of mucus and PGE2, as well as the activities of SOD and CAT.
Correspondence: Assoc. Prof. Dr Jamal Houssaini